Essandoh K, Auchus RJ, and Brody MJ. Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption. J Pathol, doi: 10.1002/path.5837. [Epub ahead of print], 2021.
Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, Accornero F, Sargent MA, Molkentin JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nat Commun, 12(1):3928, 2021.
Essandoh K, Philippe JM, Jenkins PM, and Brody MJ. Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology. Front Physiol, 11(108):1-11, 2020.
Brody MJ, Vanhoutte D, Bakshi CV, Liu R, Correll RN, Sargent MA, and Molkentin JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. J Biol Chem, 294(22):8918-8929, 2019.
Khalil H, Kanisicak O, Vagnozzi RJ, Johanesn AK, Maliken BD, Prasad V, Boyer JG, Brody MJ, Schips TG, Kilian KK, Correll RN, Kawasaki K, Nagata K, and Molkentin JD. Cell-specific ablation of Hsp47 defines collagen producing cells in the injured heart. JCI Insight, 4(15):128722, 2019.
Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nat Commun, 10(1):76, 2019.
Brody MJ, Vanhoutte D, Schips TG, Boyer JG, Bakshi CV, Sargent MA, York AJ, and Molkentin JD. Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Mol Cell Biol, 38(14), 2018.
~selected for the cover photo and chosen as a Spotlight article by the Editor
Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, and Molkentin JD. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. ELife, 6:30543, 2017.
Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V and Molkentin JD. Dissection of Thrombospondin-4 domains involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Mol Cell Biol, 36(1):2-12, 2016.
Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Rabinowitz JE, Volk T, McNally EM, and Molkentin JD. Thrombospondin expression in myofibers stabilizes muscle membranes. ELife, 5:17589, 2016.
Brody MJ and Lee Y. The role of Leucine-rich repeat containing protein 10 (LRRC10) in dilated cardiomyopathy. Front Physiol, 7(337):1-6, 2016.
Brody MJ, Feng L, Grimes AC, Hacker TA, Olson TM, Kamp TJ, Balijepalli RC, Lee Y. LRRC10 is required to maintain cardiac function in response to pressure overload. Am J Physiol Heart Circ Physiol, 310(2):H269-78, 2016.
Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ, Tallquist MD, Molkentin JD. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun, 7:12260, 2016.
Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS One, 10(6):e0130520, 2015.
Brody MJ, Cho E, Mysliwiec MR, Kim T, Carlson CD, Lee K, and Lee Y. Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4. J Mol Cell Cardiol, 62: 237-246, 2013.
Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, and Lee Y. Ablation of the cardiac-specific gene Leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One, 7(12):e51621, 2012.
Rufer ES, Hacker TA, Flentke GR, Drake VJ, Brody MJ, Lough J, Smith SM. Altered cardiac function and ventricular septal defect in avian embryos exposed to low-dose trichloroethylene. Toxicol Sci, 113(2):444-52, 2010.