The Brody Lab

The University of Michigan

The Brody lab is broadly focused on the molecular signals that underlie cardiac disease onset and progression. We are interested in understanding how intracellular signaling is compartmentalized and regionally controlled by lipid modifications that modulate the function of signaling molecules in various cell types of the heart to control cardiac physiology and pathogenesis. We utilize a combination of mouse genetics, biochemistry, and molecular and chemical biology techniques to gain insight into pathophysiological signaling mechanisms that contribute to human cardiovascular disease.